Home Featured Microbial link between Western-style diet and incidence of colorectal cancer uncovered

Microbial link between Western-style diet and incidence of colorectal cancer uncovered

by Iqra Aslam
Published: Last Updated on

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New research builds the case that a Western-style diet — rich in red and processed meat, sugar and refined grains/carbohydrates — is tied to higher risk of colorectal cancer through the intestinal microbiota.

Investigators from Brigham and Women’s Hospital with collaborators looked at data from more than 134,000 participants from two U.S.-wide prospective cohort studies. The team analyzed dietary patterns as well as DNA from Escherichia coli strains found in more than 1,000 colorectal tumors.

The team looked for bacterial strains carrying a distinct genetic island known as polyketide synthase (pks). Pks encodes an enzyme that has been shown to cause mutations in human cells. Overall, the team found that Western diet was associated with colorectal tumors containing high amounts of pks+ E. coli but not with tumors containing little to no amount of pks+ E. coli.

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“These findings support our hypothesis that Western-style diets increase colorectal cancer risk through its effect on pks+ E. coli,” said corresponding author Shuji Ogino, MD, PhD, MS, of the Program in Molecular Pathological Epidemiology in the Department of Pathology at the Brigham. “This is the first study to link Western diet with specific pathogenic bacteria in cancer. Our next question is which component of western-style diet and lifestyle relates to colorectal cancer containing this bacterial species.”

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Materials provided by Brigham and Women’s Hospital. Note: Content may be edited for style and length.

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CropForLife (August 18, 2022) Microbial link between Western-style diet and incidence of colorectal cancer uncovered. Retrieved from https://cropforlife.com/microbial-link-between-western-style-diet-and-incidence-of-colorectal-cancer-uncovered/.
"Microbial link between Western-style diet and incidence of colorectal cancer uncovered." CropForLife - August 18, 2022, https://cropforlife.com/microbial-link-between-western-style-diet-and-incidence-of-colorectal-cancer-uncovered/
CropForLife June 27, 2022 Microbial link between Western-style diet and incidence of colorectal cancer uncovered., viewed August 18, 2022,<https://cropforlife.com/microbial-link-between-western-style-diet-and-incidence-of-colorectal-cancer-uncovered/>
"Microbial link between Western-style diet and incidence of colorectal cancer uncovered." CropForLife - Accessed August 18, 2022. https://cropforlife.com/microbial-link-between-western-style-diet-and-incidence-of-colorectal-cancer-uncovered/

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